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Insider Ownership

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Name	Relationship / Title	Current Shares	Trading Activity
burge daniel j	Officer	27,108	View
Date	Type	Shares Traded	Price Range USD
03/12/2008	Statement of Ownership	0	n/a
clark edward a	Beneficial Owner (10% or more)	203,317	View
Date	Type	Shares Traded	Price Range USD
10/17/2006	Statement of Ownership	0	n/a
facet biotech corp	Beneficial Owner (10% or more)	2,243,649	View
Date	Type	Shares Traded	Price Range USD
09/01/2009	Statement of Ownership	0	n/a
fhm iii, llc	Beneficial Owner (10% or more)	1,601,766	View
Date	Type	Shares Traded	Price Range USD
10/23/2006	Acquisition (Non Open Market)	2,155,688	n/a
10/18/2006	Buy	42,384	13.00
10/17/2006	Statement of Ownership	0	n/a
gillis steven	Director	2,312,406	View
Date	Type	Shares Traded	Price Range USD
10/23/2006	Acquisition (Non Open Market)	2,288,486	n/a
10/18/2006	Buy	44,640	13.00
gillis, steven ph.d.	Beneficial Owner (10% or more)	2,209,741	View
Date	Type	Shares Traded	Price Range USD
10/23/2006	Acquisition (Non Open Market)	2,288,486	n/a
10/17/2006	Buy	44,640	13.00
heron patrick	Director	56,704	View
Date	Type	Shares Traded	Price Range USD
10/18/2006	Buy	42,384	13.00
heron patrick j	Director	1,601,766	View
Date	Type	Shares Traded	Price Range USD
10/23/2006	Acquisition (Non Open Market)	2,155,688	n/a
hove anders d	Director	1,483,474	View
Date	Type	Shares Traded	Price Range USD
10/23/2006	Acquisition (Non Open Market)	1,822,451	n/a
10/23/2006	Buy	35,181	13.00
mann david a	Director	12,935	View
Date	Type	Shares Traded	Price Range USD
09/05/2008	Buy	1,600	4.27
09/04/2008	Buy	1,400	4.20
09/03/2008	Buy	1,000	4.15
11/20/2007	Buy	4,000	10.00
12/01/2006	Buy	1,935	18.35 - 18.88
11/29/2006	Buy	3,000	18.50
mckereghan kathleen	Officer	0	View
Date	Type	Shares Traded	Price Range USD
03/12/2008	Statement of Ownership	0	n/a
mohler kendall	Officer	140,206	View
Date	Type	Shares Traded	Price Range USD
03/12/2008	Statement of Ownership	0	n/a
oxford bioscience partners iv lp	Beneficial Owner (10% or more)	2,175,510	View
Date	Type	Shares Traded	Price Range USD
10/23/2006	Acquisition (Non Open Market)	2,155,686	n/a
10/17/2006	Buy	41,614	13.00
prospect venture partners ii lp	Beneficial Owner (10% or more)	1,795,112	View
Date	Type	Shares Traded	Price Range USD
10/17/2006	Acquisition (Non Open Market)	1,822,450	n/a
10/17/2006	Buy	35,181	13.00
schnell david	Director	1,795,112	View
Date	Type	Shares Traded	Price Range USD
10/17/2006	Acquisition (Non Open Market)	1,822,450	n/a
10/17/2006	Buy	35,181	13.00
stromatt scott	Officer	0	View
Date	Type	Shares Traded	Price Range USD
03/10/2009	Statement of Ownership	0	n/a
thompson peter a	Officer	640,451	View
Date	Type	Shares Traded	Price Range USD
05/22/2009	Option Execute	126,387	0.31
11/19/2007	Buy	5,000	9.84 - 10.13
10/18/2006	Buy	1,000	13.00
vef management iv, llc	Beneficial Owner (10% or more)	36,450	View
Date	Type	Shares Traded	Price Range USD
10/23/2006	Acquisition (Non Open Market)	36,450	n/a
10/23/2006	Buy	704	13.00
venrock associates iv, l.p.	Beneficial Owner (10% or more)	1,483,474	View
Date	Type	Shares Traded	Price Range USD
10/23/2006	Acquisition (Non Open Market)	1,483,474	n/a
10/23/2006	Buy	28,637	13.00
venrock entrepreneurs fund iv, l.p.	Beneficial Owner (10% or more)	36,450	View
Date	Type	Shares Traded	Price Range USD
10/23/2006	Acquisition (Non Open Market)	36,450	n/a
10/23/2006	Buy	704	13.00
venrock management iv, llc	Beneficial Owner (10% or more)	1,483,474	View
Date	Type	Shares Traded	Price Range USD
10/23/2006	Acquisition (Non Open Market)	1,483,474	n/a
10/23/2006	Buy	28,637	13.00
venrock partners management, llc	Beneficial Owner (10% or more)	302,527	View
Date	Type	Shares Traded	Price Range USD
10/23/2006	Acquisition (Non Open Market)	302,527	n/a
10/23/2006	Buy	5,840	13.00
venrock partners, l.p.	Beneficial Owner (10% or more)	302,527	View
Date	Type	Shares Traded	Price Range USD
10/23/2006	Acquisition (Non Open Market)	302,527	n/a
10/23/2006	Buy	5,840	13.00

Stock ownership information provided by EDGAR Online. This information is based on the the lastest electronic filed with the SEC for each owner. If an owner has not filed with the SEC electronically since the Mandated Electronic Filing and Web site Posting for Forms 3, 4 and 5 SEC rule went into effect on June 30, 2003 then they will not appear on this page.

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